体外
万古霉素
金黄色葡萄球菌
二肽
体内
细菌生长
化学
肉汤微量稀释
纳米颗粒
微生物学
药理学
细菌
医学
纳米技术
肽
生物
最小抑制浓度
生物化学
材料科学
生物技术
遗传学
作者
Nitin Yadav,Virander S. Chauhan
出处
期刊:Nanomedicine
日期:2023-01-16
标识
DOI:10.2217/nnm-2022-0144
摘要
Aim: Emergence of vancomycin (Van) resistance, and usage of its higher dose and short half-life are posing a serious concern. Slow and sustained release of Van using a nanodelivery system may overcome these problems. Materials & methods: Arginine-α,β-dehydrophenylalanine (RΔF) was synthesized using solution-phase synthesis which self-assembled into nanospheres. Van was entrapped in the nanoparticles (NPs). In vitro and in vivo efficacy of Van-RΔF was determined using broth microdilution and the mouse thigh infection model, respectively. Results & conclusion: Van-RΔF NPs efficiently inhibited bacterial growth ( Staphylococcus aureus), while Van alone showed limited growth inhibition in in vitro. Intravenous administration of Van-RΔF in mice with bacterial thigh infection showed enhanced efficacy (double) compared with Van alone, which indicates its high potential for further development.
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