作用机理
抗氧化剂
机制(生物学)
药理学
药品
癌症
癌细胞
药物输送
细胞凋亡
化学
医学
生物
生物化学
体外
有机化学
哲学
认识论
内科学
作者
Manzar Alam,Summya Rashid,Kisa Fatima,Mohd Adnan,Alaa Shafie,Mohammad Salman Akhtar,A.H. Ganie,Sayed M. Eldin,Asimul Islam,Ilyas Khan,Md. Imtaiyaz Hassan
标识
DOI:10.1016/j.biopha.2023.114710
摘要
α-Mangostin (α-MG) is a natural xanthone obtained from the pericarps of mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective, antimicrobial, antioxidant, and anti-inflammatory properties, and induces apoptosis. α-MG controls cell proliferation by modulating signaling molecules, thus implicated in cancer therapy. It possesses incredible pharmacological features and modulates crucial cellular and molecular factors. Due to its lesser water solubility and pitiable target selectivity, α-MG has limited clinical application. As a known antioxidant, α-MG has gained significant attention from the scientific community, increasing interest in extensive technical and biomedical applications. Nanoparticle-based drug delivery systems were designed to improve the pharmacological features and efficiency of α-MG. This review is focused on recent developments on the therapeutic potential of α-MG in managing cancer and neurological diseases, with a special focus on its mechanism of action. In addition, we highlighted biochemical and pharmacological features, metabolism, functions, anti-inflammatory, antioxidant effects and pre-clinical applications of α-MG.
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