Tuning mucoadhesion and mucopenetration in self-assembled poly(lactic acid)-block-poly(oligoethylene glycol methacrylate) block copolymer nanoparticles by controlling side-chain lengths

ocular irritation in Sprague-Dawley rats. Coupled with the capacity of the synthetic route to easily incorporate different brush lengths and/or different functional groups into the hydrophilic block, we anticipate this approach may offer a solution in applications in which balancing mucoadhesion and mucopenetration is critical for enabling effective drug delivery.