过剩1
葡萄糖转运蛋白
癌细胞
癌症
细胞内
化学
小干扰RNA
葡萄糖氧化酶
癌症研究
肺癌
细胞生物学
转染
生物
生物化学
医学
内科学
内分泌学
酶
基因
胰岛素
遗传学
作者
Jiaqi Li,Jingyuan Yu,Qi Fang,Yongsheng Du,Xiaojun Zhang
标识
DOI:10.1002/cbic.202400239
摘要
Glucose transporter protein‐1 (Glut1), is highly expressed in many cancer types and plays a crucial role in cancer progression through enhanced glucose transport. Its overexpression is associated with aggressive tumor behavior and poor prognosis. Herein, the nucleic acids modified gold nanoparticles (AuNPs) was synthesized to deliver small interfering RNA (siRNA) against Glut1 by microRNA 21 (miR‐21) triggers toehold‐mediated strand displacement reaction for lung cancer starvation therapy. Overexpression of miR‐21 triggers toehold‐mediated strand displacement, releasing the siRNA to knockdown of Glut1 in cancer cell instead of normal cell. Furthermore, the glucose oxidase‐like activity of the AuNPs accelerates intracellular glucose consumption, promoting cancer cell starvation. The engineered AuNPs@anti‐miR‐21/siGlut1 complex inhibits cancer cell proliferation, xenograft tumor growth and promotes apoptosis through glucose starvation and ROS cascade signaling, underscoring its potential as an effective therapeutic strategy for lung cancer.
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