阿兹平
废止
苯并咪唑
磷化氢
组合化学
催化作用
基质(水族馆)
化学
有机化学
海洋学
地质学
作者
Chunjie Ni,Zhi-Hui Liang,Xiaoxing Xu,Fan Yu,Dong Zhang,Chen Chen
标识
DOI:10.1021/acs.joc.4c00011
摘要
A novel method for the synthesis of functionalized azepine derivatives has been developed through a phosphine-catalyzed [4 + 3] annulation of β'-acetoxy allenoates with benzimidazole-derived 1C,3N-dinucleophiles. This approach demonstrates high efficiency and yields ranging from moderate to excellent. The reaction exhibits a wide substrate scope under the optimized conditions. Furthermore, an initial exploration of the asymmetric variant of this reaction has been conducted, utilizing phosphine (R)-SITCP as the catalyst.
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