Near-infrared 10B-BODIPY for precise guidance of tracer imaging and treatment in boron neutron capture therapy

A new near-infrared fluorescence probe (PBA-BDP) was developed by coupling boron-10 (¹⁰B) to a phenylboronic acid (PBA)-functionalized BODIPY dye. This multifunctional probe not only delivers ¹⁰B for boron neutron capture therapy (BNCT) but also enhances tumor-specific targeting and provides dynamic insight into boron distribution during treatment.