阿霉素
体内
化学
药理学
脂质体
乳腺癌
心脏毒性
体外
癌细胞
盐酸阿霉素
缺氧(环境)
药物输送
乳腺癌化疗
癌症研究
化疗
医学
癌症
生物化学
内科学
生物
生物技术
有机化学
氧气
作者
Juanjuan Li,Chunai Gong,Xinlu Chen,Huanhuan Guo,Zongguang Tai,Nan Ding,Shen Gao,Yuan Gao
标识
DOI:10.1186/s12951-023-01874-7
摘要
Doxorubicin (Dox) has been recommended in clinical guidelines for the standard-of-care treatment of breast cancer. However, Dox therapy faces challenges such as hypoxia, acidosis, H2O2-rich conditions and condensed extracellular matrix in TME as well as low targeted ability.We developed a nanosystem H-MnO2-Dox-Col NPs based on mesoporous manganese dioxide (H-MnO2) in which Dox was loaded in the core and collagenase (Col) was wrapped in the surface. Further the H-MnO2-Dox-Col NPs were covered by a fusion membrane (MP) of inflammation-targeted RAW264.7 cell membrane and pH-sensitive liposomes to form biomimetic MP@H-MnO2-Dox-Col for in vitro and in vivo study.Our results shows that MP@H-MnO2-Dox-Col can increase the Dox effect with low cardiotoxicity based on multi-functions of effective penetration in tumor tissue, alleviating hypoxia in TME, pH sensitive drug release as well as targeted delivery of Dox.This multifunctional biomimetic nanodelivery system exhibited antitumor efficacy in vivo and in vitro, thus having potential for the treatment of breast cancer.
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