Cobalt‐Catalyzed Cascade Reaction of Ynamides and 1,3‐Dicarbonyl Compounds for Selective Synthesis of Differently Sized N‐Heterocycles

Abstract A triphenylphosphine‐ligated cobalt‐catalyzed cyclization manifold with various 1,3‐dicarbonyl compounds and halogenated N ‐allyl ynamides was accomplished under alkaline reaction conditions, facilitating the synthesis of differently sized N ‐heterocycles. A large array of products was prepared to demonstrate the selective synthesis of N ‐heterocycles of different ring sizes (5‐, 6‐, and 7‐membered rings) via cobalt catalysis. The reaction has broad substrate scope and a wide range of functional groups. magnified image