A biodegradable hydrogel based on carboxymethyl cellulose/silver nanoparticles for wound closures

• Nature-inspired hydrogel made from carboxymethyl cellulose, Aloe vera, and green-synthesized silver nanoparticles. • Hydrogel is safe, biodegradable, and highly effective in promoting tissue healing. • Strong antibacterial action and ability to support cell growth. Innovative wound sealing and healing adhesives address a crucial medical need by facilitating faster and easier application while ensuring biocompatibility, biodegradability, and antibacterial efficacy. In this study, we developed a biologically inspired bonding hydrogel using carboxymethyl cellulose (CMC) as the gel matrix, integrated with green-synthesized silver nanoparticles (AgNPs), derived from an aqueous solution of Myrtus communis seed extract, and Aloe vera (AV), to enhance antimicrobial properties. The physical properties of this biodegradable hydrogel were characterized, and the antimicrobial response was evaluated against both Staphylococcus aureus and Escherichia coli . Additionally, the in vitro scratch assay using keratinocytes, fibroblasts, and endothelial cells, involved in the regeneration processes, demonstrated its wound healing potential. Our findings suggest that this green, natural-inspired engineered biodegradable hydrogel holds promise for advanced wound dressings.