肝细胞癌
癌症研究
医学
肝癌
癌症
癌
生物
疾病
细胞凋亡
癌变
作者
Wenjuan Zhang,Hao Qiang Liu,Shuhan Zhang,Zhiyan Li,Shifan Shi,Jiahui Lu,Yingmei Gao,Qiyu Sun,Jian Li
标识
DOI：10.1007/s12672-026-04902-8
摘要
The PTTG3P/miR-142-5p/IGF2BP3 axis is a master regulator of ferroptosis in HCC. PTTG3P is a competing endogenous RNA (ceRNA) which sustains IGF2BP3-mediated ferroptosis resistance. Targeting the axis sensitizes HCC to ferroptosis and is potentially a novel therapeutic target to combat treatment resistance.
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(2025-6-4)
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