拓扑替康
医学
胶质瘤
毒性
肿瘤科
拓扑异构酶
药物输送
药理学
药品
化疗
临床研究阶段
内科学
癌症研究
体外
生物化学
化学
有机化学
作者
Jeffrey N. Bruce,Robert L. Fine,Peter Canoll,Jonathan Yun,Benjamin C. Kennedy,Steven S. Rosenfeld,Stephen A. Sands,Krishna Surapaneni,Rose Lai,Candix L. Yanes,Emilia Bagiella,Robert L. DeLaPaz
出处
期刊:Neurosurgery
[Lippincott Williams & Wilkins]
日期:2011-05-12
卷期号:69 (6): 1272-1280
被引量:156
标识
DOI:10.1227/neu.0b013e3182233e24
摘要
Topotecan by convection-enhanced delivery has significant antitumor activity at concentrations that are nontoxic to normal brain. The potential for use of this therapy as a generally effective treatment option for malignant gliomas will be tested in subsequent phase II and III trials.
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