体细胞突变
慢性淋巴细胞白血病
弥漫性大B细胞淋巴瘤
滤泡性淋巴瘤
淋巴瘤
癌症研究
生物
体细胞
起源细胞
作者
Davide Rossi,Eva Berra,Michaela Cerri,Clara Deambrogi,Caterina Barbieri,Silvia Franceschetti,Monia Lunghi,Annarita Conconi,Marco Paulli,András Matolcsy,Laura Pasqualucci,Daniela Capello,Gianluca Gaidano
出处
期刊:Haematologica
[Ferrata Storti Foundation]
日期:2006-01-01
卷期号:91 (10): 1405-1409
被引量:59
摘要
The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.
科研通智能强力驱动
Strongly Powered by AbleSci AI