串联
烷基化
化学
试剂
组合化学
表面改性
级联反应
反应条件
催化作用
有机化学
物理化学
材料科学
复合材料
作者
Krishna Gopal Ghosh,Debabrata Das,Sumit Garai,Palasetty Chandu,Devarajulu Sureshkumar
标识
DOI:10.1021/acs.joc.2c00783
摘要
A visible-light-driven organophotocatalyzed multicomponent approach has been developed for tandem direct C(sp3)-H activation and alkylation followed by trifluoromethylthiolation in a one-pot operation. We report a completely metal-free, tandem, three-component approach for the difunctionalization of activated alkenes via the photoinduced radical pathway. This protocol allows the formation of two new C(sp3)-C(sp3) and C(sp3)-SCF3 bonds using a bench-stable, easy-to-handle trifluoromethylthiolating reagent under mild reaction conditions. The generosity of this reaction is shown with a library of C(sp3)-H donors and alkenes derivatives. The reaction conditions can tolerate a wide variety of functional groups. Gram-scale synthesis using environmentally benign and straightforward conditions highlights the synthetic advancement of the methodology. Further functionalization of the final product is also successfully demonstrated.
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