Development of Novel and Efficient Catalytic Systems for C-H Activation and Application to Practical Synthesis of Pharmaceuticals

Over the past decade, C-H activation reaction in which a bond formation is accomplished by breaking otherwise inert C-H bonds, has emerged as an ideal tool for constructing molecular framework of valuable compounds such as drugs and natural products. While considerable efforts have been made to expand scope of the methodology particularly on the type of accessible C-H bonds, there are still formidable challenges that should be addressed to be involved in cost effective manufacturing process of the organic molecules. This article describes our recent accomplishments to develop efficient catalytic systems for the C-H activation and their application to practical synthesis of pharmaceuticals.