Amphiphilic Polymer Ligand-Assisted Synthesis of Highly Luminescent and Stable Perovskite Nanocrystals for Sweat Fluorescent Sensing

The weak interfacial binding affinities of the inorganic perovskite core with ligands and high density of surface defect states induce the facile detachment of surface ligands from nanocrystals (NCs), resulting in their poor colloidal stability and fluorescence in aqueous. In this work, a powerful ligand engineering strategy was proposed for eliminating the surface defects and aggregation of the NCs. Using an amphiphilic polymer octylamine-modified polyacrylic acid (OPA) as a capping ligand, the as-synthesized CsPbBr₃ NCs retain high photoluminescence intensity and stability by the modified ligand-assisted reprecipitation method. The increase in the fluorescence lifetime and NC size could also be observed, and how the NC particle size influences fluorescence lifetime was further studied. In addition, the water stability, photostability, and thermal stability were significantly improved, and the fluorescence of NCs can maintain 80.13% of the original value in water for 15 d. We further validated that the strong binding affinity of OPA and oleylamine ligands with CsPbBr₃ NCs leads to a reduction in surface trap states, and a large amount of carboxyl groups of the OPA made the NCs preserve good water solubility. In addition, the OPA has the ability of adjusting the particle size of NCs. Furthermore, a wavelength-shifted colorimetric sensor based on these NCs was constructed for detection of Cl^- in sweat, which enables the rapid and visual detection of Cl^- with high accuracy and stability. Overall, these CsPbBr₃ NCs synthesized by the ligand engineering strategy validated their wide applications in biomedical sensing fields.