A content-based image retrieval system for the diagnosis of lymphoma using blood micrographs: An incorporation of deep learning with a traditional learning approach

Lymphomas, or cancers of the lymphatic system, account for around half of all blood cancers diagnosed each year. Lymphoma is a condition that is difficult to diagnose, and accurate diagnosis is critical for effective treatment. Manual microscopic analysis of blood cells requires the involvement of medical experts, whose precision is dependent on their abilities, and it takes time. This paper describes a content-based image retrieval system that uses deep learning-based feature extraction and a traditional learning method for feature reduction to retrieve similar images from a database to aid early/initial lymphoma diagnosis. The proposed algorithm employs a pre-trained network called ResNet-101 to extract image features required to distinguish four types of cells: lymphoma cells, blasts, lymphocytes, and other cells. The issue of class imbalance is resolved by over-sampling the training data followed by data augmentation. Deep learning features are extracted using the activations of the feature layer in the pre-trained net, then dimensionality reduction techniques are used to select discriminant features for the image retrieval system. Euclidean distance is used as the similarity measure to retrieve similar images from the database. The experimentation uses a microscopic blood image dataset with 1673 leukocytes of the categories blasts, lymphoma, lymphocytes, and other cells. The proposed algorithm achieves 98.74% precision in lymphoma cell classification and 99.22% precision @10 for lymphoma cell image retrieval. Experimental findings confirm our approach's practicability and effectiveness. Extended studies endorse the idea of using the prescribed system in actual medical applications, helping doctors diagnose lymphoma, dramatically reducing human resource requirements.