癌症免疫疗法
免疫疗法
巨噬细胞
癌症研究
细胞毒性T细胞
免疫系统
癌症
癌细胞
人口
先天免疫系统
黑色素瘤
免疫学
生物
医学
生物化学
内科学
体外
环境卫生
作者
Mengyu Guo,Jing Liu,Xi Chen,Zhen You,Fene Gao,Tao Liu,Jiayu Ren,Jiaming Liu,Zecheng Xiong,Ying Liu,Yaling Wang,Huibiao Liu,Xueling Chang,Rong Cai,Chunying Chen
出处
期刊:Nano Today
[Elsevier]
日期:2022-08-01
卷期号:45: 101543-101543
被引量:8
标识
DOI:10.1016/j.nantod.2022.101543
摘要
Graphdiyne oxide (GDYO) nanosheets have remarkable electronic, mechanical, and thermal properties, which is hoped to act a better alternative for biomedical applications. Tumor-associated macrophage (TAM) is a promising cell population for nanotechnology application to cancer immunotherapy. In the present study, we found M2-like macrophages can be polarized to kill cancer cells with GDYO treatment via activation of pro-inflammatory pathways and GDYO injected intraperitoneally reduced tumor growth in a melanoma-bearing mouse model. In addition, GDYO activated cytotoxic T cells either directly or indirectly via macrophages, enhancing checkpoint inhibitor response in a breast cancer model. We expect that GDYO has invoked both the innate and adaptive arms of the immune system that are likely to enhance efficacy of cancer immunotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI