The adverse reaction analysis of statin

Objective: To analyze the adverse reactions of statins drug to provide a basis for clinical rational drug use.Methods: From January 2010 to January 2013,366 patients in hospital with the adverse drug reactions and reported were choosed and analyzed. The age,sex,happen time and adverse reactions were added up. Results: There are 190 men and 176 women,and the difference was no statistical significant( P 0. 05). There are 201 cases beyond 60 years old,and 165 cases under 60 years old,and the difference was no statistical significant( P 0. 05). The adverse reactions happened at the least time of 3 days,and the longest time of 1. 5 years. The main adverse reactions included 143 cases of gastmintestinal reactions( 39. 1%),112 cases of muscle toxicity( 30. 6%),78 cases of liver injury( 21. 3%),26 cases of liver and kidney toxicity( 7.1%),and 7 cases of insomnia( 1. 9%). Simvastatin occurred in 123 cases( 33. 6%),and it was the hightest. Conclusion: Statins adverse reactions are mainly composed of muscle and liver toxicity,in using process to monitor liver result,CK are needed to void adverse reaction.