Study on Characteristics of Bone Metabolism in Patients with Hyperthyroidism

Objective To investigate the effects of thyroid function on bonemetabolism.Methods Biochemical markers of bone metabolism such as carboxy terminal cross linked telopeptide of type Ⅰ collage (ICTP),osteocalin(OSC),parathyroid hormone (PTH) and other markers related to bone metabolism were respectively measured in 40 patients with hyperthyroidism and 40 normal subjects.Results The levels of bond resorption marker(ICTP) and bond formation markers(PICP and OSC) in experimental group were both significantly higher than those in normal subjects(P0.001).The levels of PTH showed no significant difference between two groups(P0.05).Significant positive correlations were found between ICTP and PICP, and between ICTP and FT 3 and FT 4 in patients with hyperthyroidism.Conclusion Patients with hyperthyroidism were characterized by increased function of bone resorption accompanied by increased activity of bone formation and by no secondary functional change of parathyroid.Thyroid hormone might speed up bone turnover directly,thus resulting in bone mass lose mainly by the process of bone resorption.