Objective: To investigate the effect of indexes of hemorrheology and BG in type 2 diabetes mellitus patients with using antiagglutinate drugs: Lumrolcinase and Xuesaitong. Methods: The one hundred and eighty patients were randomly divided into four groups: control group, Lumrolcinase group, Xuesaitong group, Lumrolcinase and Xuesaitong group. To examinate FBG and 2 h BG in all four groups. To examinate blood viscosity, plasma viscosity, HCT and FIB before and after treatment in three treating groups. Results: FBG and 2 h BG in treating groups were lower than control group (P0. 05-0. 01). Blood viscosity, plasma viscosity, HCT and FIB in treating groups were lower than before treatment (P 0. 05-0. 01). Conclusion: antiagglutinate drugs can improve condition of hemorrheology and enhance to control the BG.