自闭症
自闭症谱系障碍
表型
心理学
神经科学
精神科
遗传学
生物
基因
作者
Stacey J. Sukoff Rizzo
出处
期刊:Methods in molecular biology
日期:2016-01-01
卷期号:: 293-310
被引量:6
标识
DOI:10.1007/978-1-4939-3661-8_17
摘要
Treatments for repetitive behaviors in Autism Spectrum Disorders (ASD) and other neurodevelopmental disorders remain an unmet medical need. Mouse models are highly valuable tools for investigating the underlying pathophysiology, genetics, and neurocircuitry of ASD, and can also be characterized for ASD-related phenotypes including repetitive behaviors and stereotypies. This chapter describes methods that can be employed for the assessment of repetitive behavior phenotypes and the evaluation of the ability of test compounds to attenuate repetitive behaviors in mouse models of ASD.
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