Objective To study the prevalence of gingival overgrowth in patients induced by nifedipine. Methods 75 patients treated with nifedipine were periodontally examined while 134 other patients without the agent were regarded as controls. Results The prevalence of gingival overgrowth in the group of nifedipine was significantly higher than that of the controls. Conclusion It is suggested that nifedipine is a risk factor inducing gingival overgrowth.