Clinical and Pathological Analysis of Gastrointestinal Stromal Tumor

Objective To investigate the clinical and pathological features of gastrointestinal stromal tumors(GIST). Methods A retrospective analysis was conducted in 60 specimens which were texted by pathology department in our hospital from May 2008 to October 2013, the expression of CD117,CD34, SMA, S-100, Ki67 and Desmin were detected by using immunohistochemical SP method, statistical data was analysed by applying SPSS13.0software. Results The positive rates of CD117 and CD34 were respectively 96.7% and 91.7%. Desmin, SMA, S-100 and Ki-67-positive rate were 5.0%,26.7%, 8.3%, 26.7% respectively. Conclusions CD117 expresses in the vast majority of GIST, so it is a specific marker for the diagnosis of GIST. Joint CD34 and DOG1 detection can improve the diagnosis of GIST. While Ki-67 expression can regarded as a prognostic indicator.