心力衰竭
奈斯立肽
医学
失代偿
内科学
心脏病学
脑利钠肽
利钠肽
心脏病
重症监护医学
作者
Burnasheva Ga,D. А. Napalkov
出处
期刊:Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk
[Paediatrician Publishers LLC]
日期:2015-12-03
卷期号:70 (5): 568-572
被引量:6
标识
DOI:10.15690/vramn.v70.i5.1443
摘要
Natriuretic peptides were discovered in 50-70s of the XX century. BNP was more diagnostically and prognostically significant, as it is secreted directly into the ventricles of the heart. The studies demonstrated a high predictive value of increasing the level of BNP in acute decompensation of heart failure and in patients with chronic heart failure in a study of Val-HeFT It was demonstrated that monitoring the level of NT-proBNP can be used for the selection of optimal therapy, affect the course and outcome of the disease, and reduce the cost of treatment. The next step in learning BNP was to undertake attempts of their use in the therapy of heart failure. Long-term therapy BNP (drug nesiritide) improved left ventricular remodelling in patients with stable heart failure. Currently the definition of the levels of BNP and NT-proBNP is used for the diagnosis and management of patients with heart failure.
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