Olanzapine vs risperidone in treatment of behavioral and psychological symptoms of dementia

AIM:To compare the efficacies and adverse reactions of olanzapine and risperidone in the treatment of behavioral and psychological symptoms of dementia(BPSD).METHODS:Sixty-seven patients were divided into two groups.Thirty-two patients of olanzapine group took olanzapine(4.1±s 1.8)mg-d~(-1),2.5～7.5 mg·d~(-1) and 35 patients of risperidone group took risperidone(0.8±0.5)mg.d~(-1),0.25～2 mg·d~(-1).The treatment duration was 8 wk with the efficacy and adverse reactions assessed by the BEHAVE-AD and TESS, respectively.RESULTS:The improvement rates of olanzapine group and risperidone group were 50 % and 40 % respectively,there was no significant difference between two groups(P＞0.05).The scores of BEHAVE-AD of both groups before and after the treatment were in dramatically significant difference(P＜0.01).The entire rate of adverse reactions of two groups were 28 % and 49 % respectively,showing no signifcant difference between them (P＞0.05).The main adverse reactions of olanzapine consisted of sleeply(12%)and weight gain(16%). CONCLUSION:Low-dose olanzapine shows good efficacy for treating BPSD as risperidone,but with less ad- verse reactions.