Study on experimental diabetes animal model in rats induced by streptozotocin

Objective To study the experimental diabetes animal model in rats induced by streptozotocin and explore the difference in different ways. Methods The diabetic model of Wistar rats was duplicated with streptozotocin once introperitoneally or intratailvenously. The blood glucose and plasma insulin levels were detected. Results Blood glucose levels in streptozotocin groups were increased significantly as compared with control group (P 0. 01). Plasma insulin levels in streptozotocin groups were decreased significantly as compared with control group (P0. 01), while there was no significant difference between different ways(P0. 05). Conclusion The diabetic model of Wistar rats could be duplicated with streptozotocin once intrapertoneally or intratailvenously,while there was no significant difference between two ways.