Advance in production process and key manufacture technology for methionine

Methionine has been used in many industrial fields,such as organism,medication,feedstuff and foodstuff,and shows a promising market demanding and a potential application prospect.This paper briefly reviews its domestic and foreign advance in production process,including enzymatic decomposition,microbial fermentation,and chemical synthesis.Chemical synthesis,including amino lactone method,malonic ester method,catalytic alkylation by solid-liquid phase transfer and hydantoin method,is emphasized,the key manufacture technique for hydantoin hydrolysis and methionine crystallization is especially intensively described.In the end,the development direction and application perspective in the domestic market are also prospected,which suggest that modern enterprise for methionine production should be built up as soon as possible using petrochemical byproducts.