哌嗪
芳基
胺气处理
喹唑啉
组合化学
三光气
化学
有机化学
光气
烷基
作者
Guangji Zhang,Xiaobo Fu,Xinming Peng,Xiuling Li,Jianian Chen
标识
DOI:10.3184/174751913x13824453043915
摘要
A convenient and efficient synthetic approach to prepare a novel series of 4-quinazolinyl piperazine aryl ureas is reported involving a convergent route. The key intermediate 4-(1-piperazinyl)-quinazoline was produced from methyl anthranilate chlorination reaction with ter t-butyl 1-piperazinecarboxylate, and amine deprotection. On the other hand, a series of amines were transformed into isocyanates by triphosgene. Without separation, these isocyanates were treated with 4-quinazolinyl-piperazine to generate a range of final products. The synthesis was simple, the products were easy to separate, and the yields were good
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