Preparation of a Menthol/beta-Cyclodextrin Inclusion Complex Using Supercritical CO2

A menthol/β-cyclodextrin inclusion complex was produced using supercritical CO2 while varying the temperature, pressure, co-solvent, inclusion time and depressurization time. The complex resulted was characterized with X-ray diffraction, scanning electron microscopy and differential scanning calorimetry. The characterization data confirmed the production of the inclusion complex at a maximum yield of 93.75 %. The dissolution rate of the complex was signiï¬?cantly higher than those of either untreated menthol or a physical mixture of menthol and β-cyclodextrin. This work thus demonstrated that supercritical CO2 could be successfully used to achieve inclusion complexes of menthol with β-CD.