Recent Advances on Diversity Oriented Heterocycle Synthesis of Fused Quinolines and Its Biological Evaluation

During the last decade quinoline derivatives have been shown to be useful starting materials and building blocks for the synthesis of a great variety of functionalized polynuclear heterocyclic systems. This review includes most known types of heterocycles fused to quinoline or its reduced derivatives at either heterocycle or homocycle. These fused heterocycles are classified according to the ring volume starting from three membered up to seven membered cycles and divided according to the number of heteroatoms and type or position of these heteroatoms. Also the content is subdivided according to type of the produced heterocyclic derivative or the sites of fusion at quinoline substrate. The condition governed this survey is to disclose only the polynuclear heterocycles those obtained using quinoline derivatives as building blocks. Biological importance of polynuclear heterocycles containing quinolines was also discussed as a part of our present work.