In older patients with AF, low-dose edoxaban reduced stroke or systemic embolism without increasing major bleeding

ACP Journal ClubJanuary 2021In older patients with AF, low-dose edoxaban reduced stroke or systemic embolism without increasing major bleedingDaniel I. Steinberg, MDDaniel I. Steinberg, MDIcahn School of Medicine at Mount Sinai, New York, New York, USA (D.I.S.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202101190-005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationOkumura K, Akao M, Yoshida T, et al. Low-dose edoxaban in very elderly patients with atrial fibrillation. N Engl J Med. 2020;383:1735-45. https://pubmed.ncbi.nlm.nih.gov/32865374Clinical Impact RatingsGIM/FP/GP: Cardiology: Geriatrics: References1 Ansell J. Stroke prevention in atrial fibrillation in the very elderly: anticoagulant therapy is no longer a sin. [Editorial]. J Am Heart Assoc. 2017;6:e006864. [PMID: 28736386] Google Scholar2 Patti G, Lucerna M, Pecen L, et al. Thromboembolic risk, bleeding outcomes and effect of different antithrombotic strategies in very elderly patients with atrial fibrillation: a sub-analysis from the PREFER in AF (PREvention oF Thromboembolic Events–European Registry in Atrial Fibrillation). J Am Heart Assoc. 2017;6:e005657. [PMID: 28736385] Google Scholar3 Connolly SJ, Eikelboom J, Joyner C, et al. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011;364:806-17. [PMID: 21309657] Google Scholar Author, Article, and Disclosure InformationAffiliations: Icahn School of Medicine at Mount Sinai, New York, New York, USA (D.I.S.)Disclosures: The commentator has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-7312.This article was published at Annals.org on 5 January 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics January 2021Volume 174, Issue 1Page: JC5KeywordsAnticoagulantsAtrial fibrillationDrugsElderlyFallsHazard ratioHemorrhageMyocardial infarctionStroke ePublished: 5 January 2021 Issue Published: January 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...