Progress in single nucleotide polymorphism with cancer susceptibility and its clinical application

Single nucleotide polymorphisms (SNPs) are the most common genetic variants in human genome.Candidate gene, genome-wide association studies (GWASs) and exome sequencing which base on SNPs have made a great progress in identifying cancer susceptibility.The development and application of high resolutions in SNPs has played an important role in clarifying the mechanism, prevention, diagnosis and targeted therapy in cancers.(Chin J Lab Med, 2012, 35:579-584)