Exosomal noncoding RNAs in colorectal cancer

Colorectal cancer (CRC) is a commonly diagnosed malignancy with unsatisfactory survival outcomes. Recent studies indicate that noncoding RNAs (ncRNAs) can be selectively packaged into exosomes, the extracellular vesicles composed of a lipid bilayer, and delivered from donor to recipient cells, thus regulating the behavior of the recipient cells. Increasing evidence has demonstrated that exosomal ncRNAs in blood exhibit distinct expression patterns among CRC patients with or without metastasis, and healthy controls. Moreover, exosomal ncRNAs can participate in the regulation of tumor microenvironment, the establishment of pre-metastatic niches, and the induction of drug resistance via cell-to-cell communication. Intriguingly, exosomal ncRNAs have the potential to serve as biomarkers for diagnosis, prognostic prediction, and therapeutic response monitoring of patients with CRC. In this review, we summarize the emerging functions of exosomal ncRNAs during CRC development and also discuss their potential clinical application in patients with CRC.