The proceeding of biocatalysis in recent years was reviewed. In according to characteristics of the preparation of biocatalysts and biocatalysis process, a new method was approached to classified industry biocatalysis process into biocatalysis-coupled cell growth and biocatalysis-uncoupled cell growth. Some exciting examples that have been researched or applied in industry were given to show these two models of biocatalysis, the methods for biocatalysis industrializations were discussed and some suggestions for further development were proposed.