医学
长春瑞滨
化疗
宫颈癌
表阿霉素
外科
中性粒细胞减少症
顺铂
临床研究阶段
奈达铂
肿瘤科
内科学
癌症
环磷酰胺
作者
G. Di Vagno,G. Cormio,Sandro Pignata,Giovanni Scambia,M.G. Di Stefano,Rosa Tambaro,Paolo Trerotoli,Gabriella Serio,Giorgia Garganese,L. Selvaggi
出处
期刊:International Journal of Gynecological Cancer
[BMJ]
日期:2003-05-01
卷期号:13 (3): 308-312
被引量:17
标识
DOI:10.1046/j.1525-1438.2003.t01-1-13198.x
摘要
Fifty eight consecutive untreated patients with locally advanced cervical carcinoma (LACC) received neoadjuvant chemotherapy (NACT) with cisplatin (CDDP) 80 mg/sqm (day 1) + vinorelbine (VRL) 25 mg/sqm (day 1 and 8). Three cycles of chemotherapy were planned every 21 days. Within 28 days from the completion of chemotherapy patients in complete or partial response were submitted to radical hysterectomy with pelvic lymphadenectomy. On 155 cycles, hematologic toxicity was mild (G3-4 neutropenia and anemia occurred in 16% and 5%, respectively). Forty-seven patients (81%) were submitted to radical surgery; eight (14%) patients were deemed ineligible for surgery because of poor response to treatment, two (3%) for anesthesia contraindications and one (2%) refused surgery. At pathologic examination 12 patients (25%) had a complete response, one (2%) in-situ carcinoma, six (13%) residual microinvasive disease, and 28 (60%) a partial response. None had extracervical disease. Eight patients (14%) had microscopic lymph node metastases. The number of cycles administered was significantly associated with a good pathologic response. Association of CDDP and VRL as NACT in LACC appears safe and effective. Low cost and modest toxicity would support the initiation of a multicenter randomized phase III trial to compare this association with cisplatin alone.
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