化学
烯丙基重排
铱
亲核细胞
药物化学
取代反应
对映选择合成
配体(生物化学)
锂(药物)
催化作用
齿合度
立体化学
晶体结构
有机化学
内分泌学
受体
医学
生物化学
作者
Björn Bartels,Cristina Garcı́a-Yebra,Frank Röminger,Günter Helmchen
标识
DOI:10.1002/1099-0682(200210)2002:10<2569::aid-ejic2569>3.0.co;2-5
摘要
Ir-catalysed allylic alkylations of enantiomerically enriched monosubstituted allylic acetates proceed with up to 87% retention of configuration using P(OPh)3 as ligand. High regio- and enantioselectivity of up to 86% ee in asymmetric allylic alkylations of achiral or racemic substrates is achieved with monodentate phosphorus amidites as ligands. Lithium N-tosylbenzylamide was identified as a suitable nucleophile for allylic aminations. Of particular importance is the use of lithium chloride as an additive, generally leading to increased enantioselectivities. Two (π-allyl)IrIII complexes were characterised by X-ray crystal structure analysis and spectroscopic data.
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