Hydrogen Peroxide Activated Matrix Metalloproteinase Inhibitors: A Prodrug Approach

Doing double duty: A metalloproteinase inhibitor that can be activated by reactive oxygen species (ROS) has been designed to protect the blood-brain barrier (BBB) in ischemic reperfusion injury. By both neutralizing damaging ROS and inhibiting degradative metalloproteinases, a single compound can eliminate both threats to the BBB upon activation.