Application of Modified Bead Cellulose as a Carrier of Active Ingredients

Abstract Summary: A new kind of very fine disperse porous bead cellulose is modified by chemical treatments to 2,3‐dialdehyde cellulose, carboxymethyl and dihydrogenphosphate cellulose. Model drugs like benzocaine and prazosin are coupled to these modified bead celluloses by covalent and ionic linkage, respectively and compressed to tablets. Compression mixtures with low loaded benzocaine conjugates release with medium rate. Linkage of prazosin cation to the anionic derivatives of bead cellulose leads to fast release of poor soluble ionic drug.