等张回归
估计员
统计
数学
均方误差
回归
线性回归
回归分析
等渗
简单线性回归
人口
医学
环境卫生
内科学
作者
Mario Stylianou,Nancy Flournoy
出处
期刊:Biometrics
[Wiley]
日期:2002-03-01
卷期号:58 (1): 171-177
被引量:190
标识
DOI:10.1111/j.0006-341x.2002.00171.x
摘要
Summary. We are interested in finding a dose that has a prespecified toxicity rate in the target population. In this article, we investigate five estimators of the target dose to be used with the up-and-down biased coin design (BCD) Introduced By Durham and Flournoy (1994, Statistical Decision Theory and Related Topics). These estimators are derived using maximum likelihood, weighted least squares, sample averages, and isotonic regression. A linearly interpolated isotonic regression estimate is shown to be simple to derive and to perform as well as or better than the other target dose estimators in terms of mean square error and average number of subjects needed for convergence in most scenarios studied.
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