受体
生物
神经营养素
受体酪氨酸激酶
细胞生物学
受体蛋白酪氨酸激酶
信号转导
信号转导衔接蛋白
神经营养因子
神经科学
trk受体
生物化学
作者
Anders Nykjær,Thomas E. Willnow
标识
DOI:10.1016/j.tins.2012.01.003
摘要
Sortilin is a type-1 receptor expressed in neurons of the central and peripheral nervous systems. Initially considered a rather peculiar receptor resembling an intracellular sorting protein in yeast, sortilin has emerged as a key player in the regulation of neuronal viability and function. It acts as a receptor of neurotrophic factors and neuropeptides, but also as a co-receptor to cytokine receptors, tyrosine receptor kinases, G-protein coupled receptors and ion-channels. Here, we review recent findings that identified multiple roles for sortilin in the cellular transport and signaling. Furthermore, we discuss how sortilin contributes not only to the functional integrity of the nervous system during physiological conditions but also plays an important role during neuronal injury and disease processes.
科研通智能强力驱动
Strongly Powered by AbleSci AI