断点群集区域
融合基因
外显子
断点
急性早幼粒细胞白血病
遗传学
生物
早幼粒细胞白血病蛋白
基因
血液学
内含子
星团(航天器)
癌症研究
免疫学
染色体易位
维甲酸
程序设计语言
计算机科学
作者
Guillermo J. Ruíz‐Argüelles,Javier Garcés‐Eisele,Virginia Reyes‐Núñez,J. David Gómez-Rangel,Guillermo J. Ruiz‐Delgado
标识
DOI:10.1080/10428190310001657344
摘要
Acute promyelocytic leukemia is characterized the PML/RARalpha chimeric fusion gene, transcript and protein; the breakpoint cluster regions (bcr) in the PML gene may occur in 3 different sites: Intron 6 (bcr1), exon 6 (bcr2) or intron 3 (bcr3). In a 10-year period in a single institution, we studied prospectively the breakpoint cluster regions of the PML/RARalpha fusion gene in 43 Mexican Mestizo patients with APL, and found that the bcr1 represented 62.7%, the bcr2 9.3% whereas the bcr3 27.9%. The prevalence of the bcr1 subtype is significantly higher than that informed in Caucasians and similar to that in Asians; these data are consonant with those described in other Latin-American patients with APL. Since other Asian genetic markers have been found in the Indian component of the Mexican mestizos, it is possible that the Asian immigration into the Americas through the strait of Behring 12,000 years ago may account for a possible genetic susceptibility to suffer certain forms of APL.
科研通智能强力驱动
Strongly Powered by AbleSci AI