配子
生殖系
生物
交配
减数分裂
生殖细胞
配子发生
细胞生物学
有性生殖
干细胞
发育生物学
繁殖
合子
遗传学
人类受精
胚胎
胚胎发生
基因
作者
Luisa F Arias Padilla,Diana C Castañeda-Cortés,Ivana F. Rosa,Omar David Moreno Acosta,Ricardo Shohei Hattori,Rafael Henrique Nóbrega,Juan I. Fernandino
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2021-03-01
卷期号:10
被引量:2
摘要
The production of an adequate number of gametes is necessary for normal reproduction, for which the regulation of proliferation from early gonadal development to adulthood is key in both sexes. Cystic proliferation of germline stem cells is an especially important step prior to the beginning of meiosis; however, the molecular regulators of this proliferation remain elusive in vertebrates. Here, we report that ndrg1b is an important regulator of cystic proliferation in medaka. We generated mutants of ndrg1b that led to a disruption of cystic proliferation of germ cells. This loss of cystic proliferation was observed from embryogenic to adult stages, impacting the success of gamete production and reproductive parameters such as spawning and fertilization. Interestingly, the depletion of cystic proliferation also impacted male sexual behavior, with a decrease of mating vigor. These data illustrate why it is also necessary to consider gamete production capacity in order to analyze reproductive behavior.
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