Enhancing DHA synthesis in Schizochytrium limacinum by exogenous additives

To improve the yield of docosahexaenoic acid(DHA),effects of exogenous additives were investigated based on DHA synthetic metabolic pathway of Schizochytrium limacinum.Biotin,citric acid,malic acid,and lovastatin could independently improve the DHA yield of Schizochytrium limacinum.Moreover,when biotin,malic acid and lovastatin were added together,the maximum production of DHA reached 11.55 g/L,improved by 71.87% compared to the control group.