Systematic Review of Neonatal Pain Management with 25% Dextrose Versus Direct Breast Feed Milk During Painful Procedure

This systematic review is the product of 25 top published journals. The search engines adopted in this study werePubMed, Medline, CINHAL, Cochrane Library, Google Scholar, and Research gate. The inclusion criteria were:1.Papers published between 2000-2020, 2.Top tier journal articles (High quality), 3. Term Healthy neonates and preterm neonates, 4.Neonates undergoing various painful procedures and Neonates receive different pain relief interventions. The key searching words were Neonates, Painful Procedures, BCG Vaccination, 25% Dextrose. The present paper highlights that 25% dextrose and direct breastfeed milk relieves neonatal pain. The gate-control theory also discusses the idea of central control through modulation of nerve impulses in descending fibbers from the brain. The gate tends to close when cognitive activities such as distraction (e.g., breastfeeding) are processed along these fibres, therefore preventing the transmission of pain through a “descending blocking action.” This mechanism also affects various pain entities such as anxiety, anticipation, and memory of prior experiences.This paper shows the research gaps from different studies in the review of the literature. In this present study of systematic review, 25 recent multiple interventions based on RCTs studies between 2010 to 2020 were systematically reviewed using the keywords search method. The findings are discussed and research gaps related to the RCTs are listed accordingly.