双歧杆菌
益生元
体外
粘蛋白
细菌
抗体
微生物学
粪便
葡聚糖
免疫球蛋白A
生物
化学
乳酸菌
食品科学
免疫学
生物化学
免疫球蛋白G
遗传学
作者
Ayumu Horinouchi,Hirokazu Hirai,Rika Hirano,Shin Kurihara,Hiroki Takagi,Kenji Matsumoto
标识
DOI:10.1016/j.jff.2021.104759
摘要
The functional properties of indigestible glucan (IG), a newly developed water-soluble glucose polymer, on intestinal health were investigated. Of high amylose cornstarch, fructooligosaccharides, and IG, IG showed the strongest intestinal IgA induction during the 5-week experiment with BALB/cA mice (3% per diet). Next, separated IG samples, degree of polymerization (DP) ≥ 5 (High-IG) and DP ≤ 5 (Low-IG) fractions, were fed to BALB/cA mice for 9 weeks (3% per diet). High-IG consumption immediately increased the fecal IgA, whereas Low-IG consumption gradually increased it. Fecal mucin was significantly increased in the High-IG group but not in the Low-IG group. To identify utilization of High-IG and Low-IG by intestinal bacteria, in vitro assays were performed using 57 human gut bacterial strains. Few bacteria utilized High-IG, whereas more bacteria, particularly Bifidobacterium strains, utilized Low-IG. These results indicate that IG ingestion benefits the intestinal environment via strengthening the intestinal barrier function and prebiotic effects.
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