磷烯
介电谱
检出限
生物分子
材料科学
X射线光电子能谱
拉曼光谱
石墨烯
纳米技术
电化学
分析化学(期刊)
色谱法
化学
化学工程
电极
物理
光学
物理化学
工程类
作者
Sharat Chandra Barman,Md. Sharifuzzaman,Md Abu Zahed,Chani Park,Sung Wook Yoon,Shi-Peng Zhang,Hyun-Sik Kim,Hyosang Yoon,Jae Yeong Park
标识
DOI:10.1016/j.bios.2021.113287
摘要
Due to the insufficiency of binding sites for the immobilized recognition biomolecules on the immunosensing platform, cancer detection becomes challenging. Whereas, the degradation of black phosphorene (BP) in the presence of the environmental factors becomes a concerning issue for use in electrochemical sensing. In this study, BP is successfully encapsulated by polyallylamine (PAMI) to increase its stability as well as to enhance its electrochemical performance. The successful encapsulation of BP is ensured through X-ray Photoelectron spectroscopy and Raman spectroscopy, whereas the stability of black phosphorus is ensured by Zeta potential measurements and cyclic voltammetry tests. The developed BP-PAMI composite showed high stability in the ambient environment and exhibited improved electrochemical performances. The impedimetric immunosensor was developed on a BP-PAMI modified laser burned graphene (LBG) to detect interleukin-6 biomarkers using electrochemical impedance spectroscopy (EIS). Under the optimized parameters, the fabricated immunosensor demonstrated a wide linear range of 0.003-75 ng/mL, limit of detection (LOD) of 1 pg/mL. Based on the experimental analysis, the developed sensing strategy can be employed as an easy, disposable, cost-effective and highly selective point-of-care cancer detection. In addition, the developed technique can be applied broadly for detecting other biomarkers after treating with suitable biomolecules.
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