芳基
化学
催化作用
组合化学
卤化物
基质(水族馆)
分子
功能群
作者
Dejiang Zhang,Zhi Xu,Ting Tang,Liyuan Le,Cairong Wang,Nobuaki Kambe,Renhua Qiu
标识
DOI:10.1021/acs.orglett.2c00879
摘要
Herein, we describe a general method for the synthesis of unsymmetric diarylmethanes from (hetero)aryl methyl halides and Sb-aryl stibines. This protocol shows a broad substrate scope and a good functional group tolerance. Drug molecules, including beclobrate 3al and bifemelane 3as, and drug derivatives, including celecoxib 3p, ibuprofen 3ao, and probenecid 3ap, were efficiently synthesized on a gram scale. The possible mechanism is proposed on the basis of the results of control experiments.
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