酞
根茎
子宫收缩
收缩(语法)
细胞外
化学
细胞内
平滑肌
催产素
肌层
肌肉松弛剂
立体化学
汤剂
肌肉收缩
药理学
子宫
内科学
生物化学
医学
传统医学
有机化学
作者
Juan Liu,Rui Feng,Ou Dai,Hong Ni,Lu-Si Liu,Hong-Zhen Shu,Yan Lü,Cheng Peng,Liang Xiong
出处
期刊:Phytochemistry
[Elsevier]
日期:2022-06-01
卷期号:198: 113159-113159
被引量:1
标识
DOI:10.1016/j.phytochem.2022.113159
摘要
Three undescribed isoindoline alkaloids, (+)-(R)-3-butyl-3-ethoxyisoindolin-1-one, (+)-(3S,6S,7R)-3-butyl-6,7-dihydroxy-3-methoxy-4,5,6,7-tetrahydroisoindolin-1-one, and (-)-(3R,6S,7R)-3-butyl-6,7-dihydroxy-3-methoxy-4,5,6,7-tetrahydroisoindolin-1-one, along with nine known phthalides were isolated from a water decoction of the rhizomes of Ligusticum chuanxiong using chromatographic methods. Their structures and absolute configurations were determined by extensive spectroscopic analyses and ECD data calculations. The relaxant effects of the isolated compounds on uterine contractions induced by oxytocin were investigated using a rat uterine smooth muscle contraction model. Furthermore, the effects of riligustilide on extracellular Ca2+ influx and intracellular Ca2+ release were assessed using high-KCl solution-induced and oxytocin-induced uterine smooth muscle contraction in a Ca2+-free balanced salt solution. The results showed that all the tested phthalides had inhibitory effects on oxytocin-induced uterine smooth muscle contraction. Riligustilide, a phthalide dimer, was the most active. Further examinations indicated that riligustilide reduced uterine smooth muscle contraction by inhibiting extracellular Ca2+ influx and intracellular Ca2+ release.
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