化学
细胞周期检查点
细胞凋亡
钌
白花丹
亲脂性
细胞周期
细胞生长
细胞毒性
程序性细胞死亡
立体化学
生物化学
体外
生物
遗传学
催化作用
作者
Yulan Li,Xiaomin Zhu,Nan-Feng Chen,Shaoting Chen,Yang Yang,Hong Liang,Zhen-Feng Chen
标识
DOI:10.1016/j.ejmech.2022.114312
摘要
To study the antitumor activity and action mechanism of Ru(II) polypyridyl plumbagin (PLN) complexes, four complexes [Ru(PLN)(DMSO)2]Cl (Ru1), [Ru(bpy)2(PLN)](PF6) (bpy is bipyridine) (Ru2), [Ru(phen)2(PLN)](PF6) (phen is 1,10-phenanthroline) (Ru3), and [Ru(DIP)2(PLN)](PF6) (DIP is 4,7-diphenyl-1,10-phenanthroline) (Ru4) were obtained and fully characterized. Lipophilicity, cellular uptake and cytotoxicity of these Ru(II) complexes are in the order of: Ru1
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