Recent Advances in Transition-Metal-Catalyzed Asymmetric Functionalization of Enamides

Abstract Enamides, as prefunctionalized electron-rich heteroatom-substituted alkenes represent a powerful platform to synthesize useful nitrogen-containing natural products and bioactive molecules. This review discloses recent progress in the transition-metal-catalyzed enantioselective functionalization of enamides, including the Heck reaction, hydrofunctionalization, and difunctionalization, with a focus on the general scope, current limitations, stereochemical reaction control, and mechanistic aspects. 1 Introduction 2 Asymmetric Heck Reaction of Enamides 3 Asymmetric Hydrofunctionalization of Enamides 3.1 Nickel Catalysis 3.2 Copper Catalysis 3.3 Rhodium Catalysis 3.4 Iridium Catalysis 4 Asymmetric Difunctionalization of Enamides 4.1 Palladium Catalysis 4.2 Nickel Catalysis 4.3 Copper Catalysis 5 Summary and Outlook